var bibbase_data = {"data":"<img src=\"//bibbase.org/img/ajax-loader.gif\" id=\"spinner\"\n  style=\"display: none;\" alt=\"Loading..\" />\n\n<div id=\"bibbase\">\n\n  <script type=\"text/javascript\">\n    var bibbase = {\n      params: {\"bib\":\"https://api.zotero.org/users/3476755/collections/MZ3ZRTC8/items?key=ckhubDoO51X1cQZZ35NkGdxk&format=bibtex&limit=100\",\"jsonp\":\"1\",\"authorFirst\":\"1\",\"hidemenu\":\"true\",\"commas\":\"true\",\"sort\":\"author_short\",\"groupby\":\"\",\"filter\":\"authors:(Horie|堀江)\",\"host\":\"bibbase.org\"},\n      data: [{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"A single motor neuron determines the rhythm of early motor behavior in <i>Ciona</i>\",\"volume\":\"7\",\"issn\":\"2375-2548\",\"url\":\"https://www.science.org/doi/10.1126/sciadv.abl6053\",\"doi\":\"10.1126/sciadv.abl6053\",\"abstract\":\"Single motor neuron regulates rhythmic tail flick in prehatching Ciona embryo. , Recent work in tunicate supports the similarity between the motor circuits of vertebrates and basal deuterostome lineages. To understand how the rhythmic activity in motor circuits is acquired during development of protochordate Ciona , we investigated the coordination of the motor response by identifying a single pair of oscillatory motor neurons (MN2/A10.64). The MN2 neurons had Ca 2+ oscillation with an ~80-s interval that was cell autonomous even in a dissociated single cell. The Ca 2+ oscillation of MN2 coincided with the early tail flick (ETF). The spikes of the membrane potential in MN2 gradually correlated with the rhythm of ipsilateral muscle contractions in ETFs. The optogenetic experiments indicated that MN2 is a necessary and sufficient component of ETFs. These results indicate that MN2 is indispensable for the early spontaneous rhythmic motor behavior of Ciona . Our findings shed light on the understanding of development and evolution of chordate rhythmical locomotion.\",\"language\":\"en\",\"number\":\"50\",\"urldate\":\"2022-01-25\",\"journal\":\"Science Advances\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Akahoshi\"],\"firstnames\":[\"Taichi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Utsumi\"],\"firstnames\":[\"Madoka\",\"K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Oonuma\"],\"firstnames\":[\"Kouhei\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Murakami\"],\"firstnames\":[\"Makoto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Horie\"],\"firstnames\":[\"Takeo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kusakabe\"],\"firstnames\":[\"Takehiro\",\"G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Oka\"],\"firstnames\":[\"Kotaro\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hotta\"],\"firstnames\":[\"Kohji\"],\"suffixes\":[]}],\"month\":\"December\",\"year\":\"2021\",\"pages\":\"eabl6053\",\"bibtex\":\"@article{akahoshi_single_2021,\\n\\ttitle = {A single motor neuron determines the rhythm of early motor behavior in \\\\textit{{Ciona}}},\\n\\tvolume = {7},\\n\\tissn = {2375-2548},\\n\\turl = {https://www.science.org/doi/10.1126/sciadv.abl6053},\\n\\tdoi = {10.1126/sciadv.abl6053},\\n\\tabstract = {Single motor neuron regulates rhythmic tail flick in prehatching\\n              Ciona\\n              embryo.\\n            \\n          , \\n            \\n              Recent work in tunicate supports the similarity between the motor circuits of vertebrates and basal deuterostome lineages. To understand how the rhythmic activity in motor circuits is acquired during development of protochordate\\n              Ciona\\n              , we investigated the coordination of the motor response by identifying a single pair of oscillatory motor neurons (MN2/A10.64). The MN2 neurons had Ca\\n              2+\\n              oscillation with an {\\\\textasciitilde}80-s interval that was cell autonomous even in a dissociated single cell. The Ca\\n              2+\\n              oscillation of MN2 coincided with the early tail flick (ETF). The spikes of the membrane potential in MN2 gradually correlated with the rhythm of ipsilateral muscle contractions in ETFs. The optogenetic experiments indicated that MN2 is a necessary and sufficient component of ETFs. These results indicate that MN2 is indispensable for the early spontaneous rhythmic motor behavior of\\n              Ciona\\n              . Our findings shed light on the understanding of development and evolution of chordate rhythmical locomotion.},\\n\\tlanguage = {en},\\n\\tnumber = {50},\\n\\turldate = {2022-01-25},\\n\\tjournal = {Science Advances},\\n\\tauthor = {Akahoshi, Taichi and Utsumi, Madoka K. and Oonuma, Kouhei and Murakami, Makoto and Horie, Takeo and Kusakabe, Takehiro G. and Oka, Kotaro and Hotta, Kohji},\\n\\tmonth = dec,\\n\\tyear = {2021},\\n\\tpages = {eabl6053},\\n}\\n\\n\",\"author_short\":[\"Akahoshi, T.\",\"Utsumi, M. K.\",\"Oonuma, K.\",\"Murakami, M.\",\"Horie, T.\",\"Kusakabe, T. G.\",\"Oka, K.\",\"Hotta, K.\"],\"key\":\"akahoshi_single_2021\",\"id\":\"akahoshi_single_2021\",\"bibbaseid\":\"akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.science.org/doi/10.1126/sciadv.abl6053\"},\"metadata\":{\"authorlinks\":{\"horie, t\":\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\"}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, <i>Ciona intestinalis</i> Type A (<i>Ciona robusta</i>): Innervation, Gene Expression Profiles, and Phenotypes\",\"volume\":\"12\",\"issn\":\"1664-2392\",\"shorttitle\":\"Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, Ciona intestinalis Type A (Ciona robusta)\",\"url\":\"https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full\",\"doi\":\"10.3389/fendo.2021.668564\",\"abstract\":\"Oxytocin (OT) and vasopressin (VP) superfamily neuropeptides are distributed in not only vertebrates but also diverse invertebrates. However, no VPergic innervation of invertebrates has ever been documented. In the ascidian, Ciona intestinalis Type A ( Ciona robusta ), an OT/VP superfamily peptide was identified, and the Ciona vasopressin (CiVP) induces oocyte maturation and ovulation. In the present study, we characterize the innervation and phenotypes of genetically modified Ciona : CiVP promoter-Venus transgenic and CiVP mutants. CiVP promoter-Venus transgenic Ciona demonstrated that CiVP gene was highly expressed in the cerebral ganglion and several nerves. Fluorescence was also detected in the ovary of young CiVP promoter-Venus transgenic ascidians, suggesting that the CiVP gene is also expressed temporarily in the ovary of young ascidians. Furthermore, a marked decrease of post-vitellogenic (stage III) follicles was observed in the ovary of CiVP mutants, whereas pre-vitellogenic (stage I) and vitellogenic (stage II) follicles were increased in the mutant ovary, compared with that of wildtype Ciona . Gene expression profiles showed that the expression of various genes, including genes related to ovarian follicle growth, was altered in the ovary of CiVP mutants. Altogether, these results indicated that CiVP, mainly as a neuropeptide, plays pivotal roles in diverse biological functions, including growth of early-stage ovarian follicles via regulation of the expression of a wide variety of genes. This is the first report describing a VP gene promoter-transgenic and VP gene-edited invertebrate and also on its gene expression profiles and phenotypes.\",\"urldate\":\"2021-08-06\",\"journal\":\"Frontiers in Endocrinology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Kawada\"],\"firstnames\":[\"Tsuyoshi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shiraishi\"],\"firstnames\":[\"Akira\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Matsubara\"],\"firstnames\":[\"Shin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hozumi\"],\"firstnames\":[\"Akiko\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Horie\"],\"firstnames\":[\"Takeo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sasakura\"],\"firstnames\":[\"Yasunori\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Satake\"],\"firstnames\":[\"Honoo\"],\"suffixes\":[]}],\"month\":\"May\",\"year\":\"2021\",\"pages\":\"668564\",\"bibtex\":\"@article{kawada_vasopressin_2021,\\n\\ttitle = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, \\\\textit{{Ciona} intestinalis} {Type} {A} (\\\\textit{{Ciona} robusta}): {Innervation}, {Gene} {Expression} {Profiles}, and {Phenotypes}},\\n\\tvolume = {12},\\n\\tissn = {1664-2392},\\n\\tshorttitle = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, {Ciona} intestinalis {Type} {A} ({Ciona} robusta)},\\n\\turl = {https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full},\\n\\tdoi = {10.3389/fendo.2021.668564},\\n\\tabstract = {Oxytocin (OT) and vasopressin (VP) superfamily neuropeptides are distributed in not only vertebrates but also diverse invertebrates. However, no VPergic innervation of invertebrates has ever been documented. In the ascidian,\\n              Ciona intestinalis\\n              Type A (\\n              Ciona robusta\\n              ), an OT/VP superfamily peptide was identified, and the\\n              Ciona\\n              vasopressin (CiVP) induces oocyte maturation and ovulation. In the present study, we characterize the innervation and phenotypes of genetically modified\\n              Ciona\\n              :\\n              CiVP\\n              promoter-Venus transgenic and\\n              CiVP\\n              mutants.\\n              CiVP\\n              promoter-Venus transgenic\\n              Ciona\\n              demonstrated that\\n              CiVP\\n              gene was highly expressed in the cerebral ganglion and several nerves. Fluorescence was also detected in the ovary of young\\n              CiVP\\n              promoter-Venus transgenic ascidians, suggesting that the\\n              CiVP\\n              gene is also expressed temporarily in the ovary of young ascidians. Furthermore, a marked decrease of post-vitellogenic (stage III) follicles was observed in the ovary of\\n              CiVP\\n              mutants, whereas pre-vitellogenic (stage I) and vitellogenic (stage II) follicles were increased in the mutant ovary, compared with that of wildtype\\n              Ciona\\n              . Gene expression profiles showed that the expression of various genes, including genes related to ovarian follicle growth, was altered in the ovary of\\n              CiVP\\n              mutants. Altogether, these results indicated that CiVP, mainly as a neuropeptide, plays pivotal roles in diverse biological functions, including growth of early-stage ovarian follicles\\n              via\\n              regulation of the expression of a wide variety of genes. This is the first report describing a\\n              VP\\n              gene promoter-transgenic and\\n              VP\\n              gene-edited invertebrate and also on its gene expression profiles and phenotypes.},\\n\\turldate = {2021-08-06},\\n\\tjournal = {Frontiers in Endocrinology},\\n\\tauthor = {Kawada, Tsuyoshi and Shiraishi, Akira and Matsubara, Shin and Hozumi, Akiko and Horie, Takeo and Sasakura, Yasunori and Satake, Honoo},\\n\\tmonth = may,\\n\\tyear = {2021},\\n\\tpages = {668564},\\n}\\n\\n\",\"author_short\":[\"Kawada, T.\",\"Shiraishi, A.\",\"Matsubara, S.\",\"Hozumi, A.\",\"Horie, T.\",\"Sasakura, Y.\",\"Satake, H.\"],\"key\":\"kawada_vasopressin_2021\",\"id\":\"kawada_vasopressin_2021\",\"bibbaseid\":\"kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full\"},\"metadata\":{\"authorlinks\":{\"horie, t\":\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\"}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Evolution of Developmental Programs for the Midline Structures in Chordates: Insights From Gene Regulation in the Floor Plate and Hypochord Homologues of <i>Ciona</i> Embryos\",\"volume\":\"9\",\"issn\":\"2296-634X\",\"shorttitle\":\"Evolution of Developmental Programs for the Midline Structures in Chordates\",\"url\":\"https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full\",\"doi\":\"10.3389/fcell.2021.704367\",\"abstract\":\"In vertebrate embryos, dorsal midline tissues, including the notochord, the prechordal plate, and the floor plate, play important roles in patterning of the central nervous system, somites, and endodermal tissues by producing extracellular signaling molecules, such as Sonic hedgehog (Shh). In Ciona , hedgehog.b , one of the two hedgehog genes, is expressed in the floor plate of the embryonic neural tube, while none of the hedgehog genes are expressed in the notochord. We have identified a cis -regulatory region of hedgehog.b that was sufficient to drive a reporter gene expression in the floor plate. The hedgehog.b cis -regulatory region also drove ectopic expression of the reporter gene in the endodermal strand, suggesting that the floor plate and the endodermal strand share a part of their gene regulatory programs. The endodermal strand occupies the same topographic position of the embryo as does the vertebrate hypochord, which consists of a row of single cells lined up immediately ventral to the notochord. The hypochord shares expression of several genes with the floor plate, including Shh and FoxA , and play a role in dorsal aorta development. Whole-embryo single-cell transcriptome analysis identified a number of genes specifically expressed in both the floor plate and the endodermal strand in Ciona tailbud embryos. A Ciona FoxA ortholog FoxA.a is shown to be a candidate transcriptional activator for the midline gene battery. The present findings suggest an ancient evolutionary origin of a common developmental program for the midline structures in Olfactores.\",\"urldate\":\"2021-08-06\",\"journal\":\"Frontiers in Cell and Developmental Biology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Oonuma\"],\"firstnames\":[\"Kouhei\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yamamoto\"],\"firstnames\":[\"Maho\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Moritsugu\"],\"firstnames\":[\"Naho\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Okawa\"],\"firstnames\":[\"Nanako\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mukai\"],\"firstnames\":[\"Megumi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sotani\"],\"firstnames\":[\"Miku\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsunemi\"],\"firstnames\":[\"Shuto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sugimoto\"],\"firstnames\":[\"Haruka\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nakagome\"],\"firstnames\":[\"Eri\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hasegawa\"],\"firstnames\":[\"Yuichi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shimai\"],\"firstnames\":[\"Kotaro\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Horie\"],\"firstnames\":[\"Takeo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kusakabe\"],\"firstnames\":[\"Takehiro\",\"G.\"],\"suffixes\":[]}],\"month\":\"June\",\"year\":\"2021\",\"pages\":\"704367\",\"bibtex\":\"@article{oonuma_evolution_2021,\\n\\ttitle = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}: {Insights} {From} {Gene} {Regulation} in the {Floor} {Plate} and {Hypochord} {Homologues} of \\\\textit{{Ciona}} {Embryos}},\\n\\tvolume = {9},\\n\\tissn = {2296-634X},\\n\\tshorttitle = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}},\\n\\turl = {https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full},\\n\\tdoi = {10.3389/fcell.2021.704367},\\n\\tabstract = {In vertebrate embryos, dorsal midline tissues, including the notochord, the prechordal plate, and the floor plate, play important roles in patterning of the central nervous system, somites, and endodermal tissues by producing extracellular signaling molecules, such as Sonic hedgehog (Shh). In\\n              Ciona\\n              ,\\n              hedgehog.b\\n              , one of the two\\n              hedgehog\\n              genes, is expressed in the floor plate of the embryonic neural tube, while none of the\\n              hedgehog\\n              genes are expressed in the notochord. We have identified a\\n              cis\\n              -regulatory region of\\n              hedgehog.b\\n              that was sufficient to drive a reporter gene expression in the floor plate. The\\n              hedgehog.b cis\\n              -regulatory region also drove ectopic expression of the reporter gene in the endodermal strand, suggesting that the floor plate and the endodermal strand share a part of their gene regulatory programs. The endodermal strand occupies the same topographic position of the embryo as does the vertebrate hypochord, which consists of a row of single cells lined up immediately ventral to the notochord. The hypochord shares expression of several genes with the floor plate, including\\n              Shh\\n              and\\n              FoxA\\n              , and play a role in dorsal aorta development. Whole-embryo single-cell transcriptome analysis identified a number of genes specifically expressed in both the floor plate and the endodermal strand in\\n              Ciona\\n              tailbud embryos. A\\n              Ciona\\n              FoxA ortholog FoxA.a is shown to be a candidate transcriptional activator for the midline gene battery. The present findings suggest an ancient evolutionary origin of a common developmental program for the midline structures in Olfactores.},\\n\\turldate = {2021-08-06},\\n\\tjournal = {Frontiers in Cell and Developmental Biology},\\n\\tauthor = {Oonuma, Kouhei and Yamamoto, Maho and Moritsugu, Naho and Okawa, Nanako and Mukai, Megumi and Sotani, Miku and Tsunemi, Shuto and Sugimoto, Haruka and Nakagome, Eri and Hasegawa, Yuichi and Shimai, Kotaro and Horie, Takeo and Kusakabe, Takehiro G.},\\n\\tmonth = jun,\\n\\tyear = {2021},\\n\\tpages = {704367},\\n}\\n\\n\",\"author_short\":[\"Oonuma, K.\",\"Yamamoto, M.\",\"Moritsugu, N.\",\"Okawa, N.\",\"Mukai, M.\",\"Sotani, M.\",\"Tsunemi, S.\",\"Sugimoto, H.\",\"Nakagome, E.\",\"Hasegawa, Y.\",\"Shimai, K.\",\"Horie, T.\",\"Kusakabe, T. G.\"],\"key\":\"oonuma_evolution_2021\",\"id\":\"oonuma_evolution_2021\",\"bibbaseid\":\"oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full\"},\"metadata\":{\"authorlinks\":{\"horie, t\":\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\"}},\"html\":\"\"}],\n      metadata: {\"owner\":\"horie, t\",\"authorlinks\":{\"horie, t\":\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\"}},\n      ownerID: \"7trKDpm8ssFuSLXtn\"\n    };\n  </script>\n\n  <script type=\"text/javascript\">\n  var site$;\n  if (typeof $ != 'undefined') {\n    console.log('existing jquery: storing and then restoring');\n    site$ = $;\n    $ = null;\n  }\n  </script>\n\n  <script src=\"https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js\">\n  </script>\n  <script type=\"text/javascript\">\n  if (site$) {\n    console.log('existing jquery: avoiding conflict and restoring');\n    bb$ = $.noConflict(true);\n    $ = site$;\n  } else {\n    bb$ = $;\n  }\n  </script>\n\n  <script src=\"//bibbase.org/js/bibbase.min.js\"\n          type=\"text/javascript\">\n  </script>\n\n  <script type=\"text/javascript\"\n          src=\"https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\n  </script>\n  <script type=\"text/x-mathjax-config\">\n    MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['\\\\(','\\\\)']]},\n                        skipTags: [\"body\"],\n                        processClass: \"bibbase_paper\"});\n  </script>\n\n  <style>\n  @media print {\n    .dontprint {\n        display: none !important;\n    }\n\n  .bibbase_group {\n    background-color: #E0E0E0;\n    font-style: italic;\n    font-size: larger;\n    text-shadow: 0px 0px 3px #FFFFFF;\n    border-radius: 4px 4px 4px 4px;\n    -moz-border-radius: 4px 4px 4px 4px;\n    -webkit-border-radius: 4px;\n    padding: 5px 40px 5px;\n    margin-top: 10px;\n    margin-bottom: 5px;\n    cursor: pointer;\n  }\n\n  .bibbase_paper {\n    margin-bottom: 5px;\n  }\n\n  }\n  </style>\n\n  \n  <div style=\"float: right; margin-right: 10px; margin-top: 10px; text-align: right; font-size: 12px\">\n    generated by\n    <a href=\"//bibbase.org\"\n       onclick=\"trackOutboundLink('bibbase', 'logo clicked', window.location.href, '//bibbase.org'); return false;\">\n      <img src=\"//bibbase.org/img/logo.svg\"\n           style=\"vertical-align: middle; margin-left: 3px; height: 16px;\"/\n           alt=\"bibbase.org\"\n           title=\"BibBase – The easiest way to maintain your publications page.\"\n        ></a>\n    \n  </div>\n  \n\n  <div id=\"bibbase_header\" class=\"dontprint\" style=\"display: none\">\n\n    <ul class=\"nav nav-pills\" style=\"margin: 0px;\">\n\n      <li class=\"dropdown\" id=\"groupby_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\">\n          Group by\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li class=\"groupby year\"><a onclick=\"groupby('year')\">\n            Year</a>\n        </li>\n        <li class=\"groupby author\"><a onclick=\"groupby('author_short')\">\n            Author</a>\n        </li>\n        <li class=\"groupby type\"><a onclick=\"groupby('type')\">\n            Type</a>\n        </li>\n        <li class=\"groupby keyword\"><a onclick=\"groupby('keyword')\">\n            Keyword</a>\n        </li>\n        <li class=\"groupby downloads\"><a onclick=\"groupby('downloads')\">\n            Downloads</a>\n        </li>\n      </ul>\n      </li>\n\n\n      <li class=\"dropdown\" id=\"menu_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\" alt=\"controls\">\n          <i class=\"fa fa-reorder\" alt=\"controls\"></i>\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li>\n          <a onclick=\"toggleAll()\">\n            <i class=\"fa fa-chevron-down fa-fw\"></i> Expand/Collapse All\n          </a>\n        </li>\n        <li>\n          <a download=\"items\" href=\"data:text/bibtex;base64,@article{akahoshi_single_2021,
	title = {A single motor neuron determines the rhythm of early motor behavior in \textit{{Ciona}}},
	volume = {7},
	issn = {2375-2548},
	url = {https://www.science.org/doi/10.1126/sciadv.abl6053},
	doi = {10.1126/sciadv.abl6053},
	abstract = {Single motor neuron regulates rhythmic tail flick in prehatching
              Ciona
              embryo.
            
          , 
            
              Recent work in tunicate supports the similarity between the motor circuits of vertebrates and basal deuterostome lineages. To understand how the rhythmic activity in motor circuits is acquired during development of protochordate
              Ciona
              , we investigated the coordination of the motor response by identifying a single pair of oscillatory motor neurons (MN2/A10.64). The MN2 neurons had Ca
              2+
              oscillation with an {\textasciitilde}80-s interval that was cell autonomous even in a dissociated single cell. The Ca
              2+
              oscillation of MN2 coincided with the early tail flick (ETF). The spikes of the membrane potential in MN2 gradually correlated with the rhythm of ipsilateral muscle contractions in ETFs. The optogenetic experiments indicated that MN2 is a necessary and sufficient component of ETFs. These results indicate that MN2 is indispensable for the early spontaneous rhythmic motor behavior of
              Ciona
              . Our findings shed light on the understanding of development and evolution of chordate rhythmical locomotion.},
	language = {en},
	number = {50},
	urldate = {2022-01-25},
	journal = {Science Advances},
	author = {Akahoshi, Taichi and Utsumi, Madoka K. and Oonuma, Kouhei and Murakami, Makoto and Horie, Takeo and Kusakabe, Takehiro G. and Oka, Kotaro and Hotta, Kohji},
	month = dec,
	year = {2021},
	pages = {eabl6053},
}



@article{kawada_vasopressin_2021,
	title = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, \textit{{Ciona} intestinalis} {Type} {A} (\textit{{Ciona} robusta}): {Innervation}, {Gene} {Expression} {Profiles}, and {Phenotypes}},
	volume = {12},
	issn = {1664-2392},
	shorttitle = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, {Ciona} intestinalis {Type} {A} ({Ciona} robusta)},
	url = {https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full},
	doi = {10.3389/fendo.2021.668564},
	abstract = {Oxytocin (OT) and vasopressin (VP) superfamily neuropeptides are distributed in not only vertebrates but also diverse invertebrates. However, no VPergic innervation of invertebrates has ever been documented. In the ascidian,
              Ciona intestinalis
              Type A (
              Ciona robusta
              ), an OT/VP superfamily peptide was identified, and the
              Ciona
              vasopressin (CiVP) induces oocyte maturation and ovulation. In the present study, we characterize the innervation and phenotypes of genetically modified
              Ciona
              :
              CiVP
              promoter-Venus transgenic and
              CiVP
              mutants.
              CiVP
              promoter-Venus transgenic
              Ciona
              demonstrated that
              CiVP
              gene was highly expressed in the cerebral ganglion and several nerves. Fluorescence was also detected in the ovary of young
              CiVP
              promoter-Venus transgenic ascidians, suggesting that the
              CiVP
              gene is also expressed temporarily in the ovary of young ascidians. Furthermore, a marked decrease of post-vitellogenic (stage III) follicles was observed in the ovary of
              CiVP
              mutants, whereas pre-vitellogenic (stage I) and vitellogenic (stage II) follicles were increased in the mutant ovary, compared with that of wildtype
              Ciona
              . Gene expression profiles showed that the expression of various genes, including genes related to ovarian follicle growth, was altered in the ovary of
              CiVP
              mutants. Altogether, these results indicated that CiVP, mainly as a neuropeptide, plays pivotal roles in diverse biological functions, including growth of early-stage ovarian follicles
              via
              regulation of the expression of a wide variety of genes. This is the first report describing a
              VP
              gene promoter-transgenic and
              VP
              gene-edited invertebrate and also on its gene expression profiles and phenotypes.},
	urldate = {2021-08-06},
	journal = {Frontiers in Endocrinology},
	author = {Kawada, Tsuyoshi and Shiraishi, Akira and Matsubara, Shin and Hozumi, Akiko and Horie, Takeo and Sasakura, Yasunori and Satake, Honoo},
	month = may,
	year = {2021},
	pages = {668564},
}



@article{oonuma_evolution_2021,
	title = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}: {Insights} {From} {Gene} {Regulation} in the {Floor} {Plate} and {Hypochord} {Homologues} of \textit{{Ciona}} {Embryos}},
	volume = {9},
	issn = {2296-634X},
	shorttitle = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}},
	url = {https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full},
	doi = {10.3389/fcell.2021.704367},
	abstract = {In vertebrate embryos, dorsal midline tissues, including the notochord, the prechordal plate, and the floor plate, play important roles in patterning of the central nervous system, somites, and endodermal tissues by producing extracellular signaling molecules, such as Sonic hedgehog (Shh). In
              Ciona
              ,
              hedgehog.b
              , one of the two
              hedgehog
              genes, is expressed in the floor plate of the embryonic neural tube, while none of the
              hedgehog
              genes are expressed in the notochord. We have identified a
              cis
              -regulatory region of
              hedgehog.b
              that was sufficient to drive a reporter gene expression in the floor plate. The
              hedgehog.b cis
              -regulatory region also drove ectopic expression of the reporter gene in the endodermal strand, suggesting that the floor plate and the endodermal strand share a part of their gene regulatory programs. The endodermal strand occupies the same topographic position of the embryo as does the vertebrate hypochord, which consists of a row of single cells lined up immediately ventral to the notochord. The hypochord shares expression of several genes with the floor plate, including
              Shh
              and
              FoxA
              , and play a role in dorsal aorta development. Whole-embryo single-cell transcriptome analysis identified a number of genes specifically expressed in both the floor plate and the endodermal strand in
              Ciona
              tailbud embryos. A
              Ciona
              FoxA ortholog FoxA.a is shown to be a candidate transcriptional activator for the midline gene battery. The present findings suggest an ancient evolutionary origin of a common developmental program for the midline structures in Olfactores.},
	urldate = {2021-08-06},
	journal = {Frontiers in Cell and Developmental Biology},
	author = {Oonuma, Kouhei and Yamamoto, Maho and Moritsugu, Naho and Okawa, Nanako and Mukai, Megumi and Sotani, Miku and Tsunemi, Shuto and Sugimoto, Haruka and Nakagome, Eri and Hasegawa, Yuichi and Shimai, Kotaro and Horie, Takeo and Kusakabe, Takehiro G.},
	month = jun,
	year = {2021},
	pages = {704367},
}

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K., Oonuma, K., Murakami, M., <a class=\"bibbase author link\" href=\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\">Horie, T.</a>, Kusakabe, T. G., Oka, K.,  &amp; Hotta, K.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.science.org/doi/10.1126/sciadv.abl6053\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021', 'https://www.science.org/doi/10.1126/sciadv.abl6053', event);\">\n    A single motor neuron determines the rhythm of early motor behavior in <i>Ciona</i>.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Science Advances</i>, 7(50): eabl6053. December 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.science.org/doi/10.1126/sciadv.abl6053\"\n     onclick=\"log_download('akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021', 'https://www.science.org/doi/10.1126/sciadv.abl6053', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"A single motor neuron determines the rhythm of early motor behavior in &lt;i&gt;Ciona&lt;/i&gt; [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1126/sciadv.abl6053\"\n     onclick=\"log_download('akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021', 'http://doi.org/10.1126/sciadv.abl6053', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('akahoshi-utsumi-oonuma-murakami-horie-kusakabe-oka-hotta-asinglemotorneurondeterminestherhythmofearlymotorbehaviorinicionai-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{akahoshi_single_2021,\n\ttitle = {A single motor neuron determines the rhythm of early motor behavior in \\textit{{Ciona}}},\n\tvolume = {7},\n\tissn = {2375-2548},\n\turl = {https://www.science.org/doi/10.1126/sciadv.abl6053},\n\tdoi = {10.1126/sciadv.abl6053},\n\tabstract = {Single motor neuron regulates rhythmic tail flick in prehatching\n              Ciona\n              embryo.\n            \n          , \n            \n              Recent work in tunicate supports the similarity between the motor circuits of vertebrates and basal deuterostome lineages. To understand how the rhythmic activity in motor circuits is acquired during development of protochordate\n              Ciona\n              , we investigated the coordination of the motor response by identifying a single pair of oscillatory motor neurons (MN2/A10.64). The MN2 neurons had Ca\n              2+\n              oscillation with an {\\textasciitilde}80-s interval that was cell autonomous even in a dissociated single cell. The Ca\n              2+\n              oscillation of MN2 coincided with the early tail flick (ETF). The spikes of the membrane potential in MN2 gradually correlated with the rhythm of ipsilateral muscle contractions in ETFs. The optogenetic experiments indicated that MN2 is a necessary and sufficient component of ETFs. These results indicate that MN2 is indispensable for the early spontaneous rhythmic motor behavior of\n              Ciona\n              . Our findings shed light on the understanding of development and evolution of chordate rhythmical locomotion.},\n\tlanguage = {en},\n\tnumber = {50},\n\turldate = {2022-01-25},\n\tjournal = {Science Advances},\n\tauthor = {Akahoshi, Taichi and Utsumi, Madoka K. and Oonuma, Kouhei and Murakami, Makoto and Horie, Takeo and Kusakabe, Takehiro G. and Oka, Kotaro and Hotta, Kohji},\n\tmonth = dec,\n\tyear = {2021},\n\tpages = {eabl6053},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Single motor neuron regulates rhythmic tail flick in prehatching Ciona embryo. , Recent work in tunicate supports the similarity between the motor circuits of vertebrates and basal deuterostome lineages. To understand how the rhythmic activity in motor circuits is acquired during development of protochordate Ciona , we investigated the coordination of the motor response by identifying a single pair of oscillatory motor neurons (MN2/A10.64). The MN2 neurons had Ca 2+ oscillation with an ~80-s interval that was cell autonomous even in a dissociated single cell. The Ca 2+ oscillation of MN2 coincided with the early tail flick (ETF). The spikes of the membrane potential in MN2 gradually correlated with the rhythm of ipsilateral muscle contractions in ETFs. The optogenetic experiments indicated that MN2 is a necessary and sufficient component of ETFs. These results indicate that MN2 is indispensable for the early spontaneous rhythmic motor behavior of Ciona . Our findings shed light on the understanding of development and evolution of chordate rhythmical locomotion.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_author\">\n  Kawada, T., Shiraishi, A., Matsubara, S., Hozumi, A., <a class=\"bibbase author link\" href=\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\">Horie, T.</a>, Sasakura, Y.,  &amp; Satake, H.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021', 'https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full', event);\">\n    Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, <i>Ciona intestinalis</i> Type A (<i>Ciona robusta</i>): Innervation, Gene Expression Profiles, and Phenotypes.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Frontiers in Endocrinology</i>, 12: 668564. May 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full\"\n     onclick=\"log_download('kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021', 'https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, &lt;i&gt;Ciona intestinalis&lt;/i&gt; Type A (&lt;i&gt;Ciona robusta&lt;/i&gt;): Innervation, Gene Expression Profiles, and Phenotypes [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.3389/fendo.2021.668564\"\n     onclick=\"log_download('kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021', 'http://doi.org/10.3389/fendo.2021.668564', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('kawada-shiraishi-matsubara-hozumi-horie-sasakura-satake-vasopressinpromotertransgenicandvasopressingeneeditedascidianicionaintestinalisitypeaicionarobustaiinnervationgeneexpressionprofilesandphenotypes-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{kawada_vasopressin_2021,\n\ttitle = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, \\textit{{Ciona} intestinalis} {Type} {A} (\\textit{{Ciona} robusta}): {Innervation}, {Gene} {Expression} {Profiles}, and {Phenotypes}},\n\tvolume = {12},\n\tissn = {1664-2392},\n\tshorttitle = {Vasopressin {Promoter} {Transgenic} and {Vasopressin} {Gene}-{Edited} {Ascidian}, {Ciona} intestinalis {Type} {A} ({Ciona} robusta)},\n\turl = {https://www.frontiersin.org/articles/10.3389/fendo.2021.668564/full},\n\tdoi = {10.3389/fendo.2021.668564},\n\tabstract = {Oxytocin (OT) and vasopressin (VP) superfamily neuropeptides are distributed in not only vertebrates but also diverse invertebrates. However, no VPergic innervation of invertebrates has ever been documented. In the ascidian,\n              Ciona intestinalis\n              Type A (\n              Ciona robusta\n              ), an OT/VP superfamily peptide was identified, and the\n              Ciona\n              vasopressin (CiVP) induces oocyte maturation and ovulation. In the present study, we characterize the innervation and phenotypes of genetically modified\n              Ciona\n              :\n              CiVP\n              promoter-Venus transgenic and\n              CiVP\n              mutants.\n              CiVP\n              promoter-Venus transgenic\n              Ciona\n              demonstrated that\n              CiVP\n              gene was highly expressed in the cerebral ganglion and several nerves. Fluorescence was also detected in the ovary of young\n              CiVP\n              promoter-Venus transgenic ascidians, suggesting that the\n              CiVP\n              gene is also expressed temporarily in the ovary of young ascidians. Furthermore, a marked decrease of post-vitellogenic (stage III) follicles was observed in the ovary of\n              CiVP\n              mutants, whereas pre-vitellogenic (stage I) and vitellogenic (stage II) follicles were increased in the mutant ovary, compared with that of wildtype\n              Ciona\n              . Gene expression profiles showed that the expression of various genes, including genes related to ovarian follicle growth, was altered in the ovary of\n              CiVP\n              mutants. Altogether, these results indicated that CiVP, mainly as a neuropeptide, plays pivotal roles in diverse biological functions, including growth of early-stage ovarian follicles\n              via\n              regulation of the expression of a wide variety of genes. This is the first report describing a\n              VP\n              gene promoter-transgenic and\n              VP\n              gene-edited invertebrate and also on its gene expression profiles and phenotypes.},\n\turldate = {2021-08-06},\n\tjournal = {Frontiers in Endocrinology},\n\tauthor = {Kawada, Tsuyoshi and Shiraishi, Akira and Matsubara, Shin and Hozumi, Akiko and Horie, Takeo and Sasakura, Yasunori and Satake, Honoo},\n\tmonth = may,\n\tyear = {2021},\n\tpages = {668564},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Oxytocin (OT) and vasopressin (VP) superfamily neuropeptides are distributed in not only vertebrates but also diverse invertebrates. However, no VPergic innervation of invertebrates has ever been documented. In the ascidian, Ciona intestinalis Type A ( Ciona robusta ), an OT/VP superfamily peptide was identified, and the Ciona vasopressin (CiVP) induces oocyte maturation and ovulation. In the present study, we characterize the innervation and phenotypes of genetically modified Ciona : CiVP promoter-Venus transgenic and CiVP mutants. CiVP promoter-Venus transgenic Ciona demonstrated that CiVP gene was highly expressed in the cerebral ganglion and several nerves. Fluorescence was also detected in the ovary of young CiVP promoter-Venus transgenic ascidians, suggesting that the CiVP gene is also expressed temporarily in the ovary of young ascidians. Furthermore, a marked decrease of post-vitellogenic (stage III) follicles was observed in the ovary of CiVP mutants, whereas pre-vitellogenic (stage I) and vitellogenic (stage II) follicles were increased in the mutant ovary, compared with that of wildtype Ciona . Gene expression profiles showed that the expression of various genes, including genes related to ovarian follicle growth, was altered in the ovary of CiVP mutants. Altogether, these results indicated that CiVP, mainly as a neuropeptide, plays pivotal roles in diverse biological functions, including growth of early-stage ovarian follicles via regulation of the expression of a wide variety of genes. This is the first report describing a VP gene promoter-transgenic and VP gene-edited invertebrate and also on its gene expression profiles and phenotypes.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_author\">\n  Oonuma, K., Yamamoto, M., Moritsugu, N., Okawa, N., Mukai, M., Sotani, M., Tsunemi, S., Sugimoto, H., Nakagome, E., Hasegawa, Y., Shimai, K., <a class=\"bibbase author link\" href=\"https://www.shimoda.tsukuba.ac.jp/staff_horie.html\">Horie, T.</a>,  &amp; Kusakabe, T. G.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021', 'https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full', event);\">\n    Evolution of Developmental Programs for the Midline Structures in Chordates: Insights From Gene Regulation in the Floor Plate and Hypochord Homologues of <i>Ciona</i> Embryos.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Frontiers in Cell and Developmental Biology</i>, 9: 704367. June 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full\"\n     onclick=\"log_download('oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021', 'https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Evolution of Developmental Programs for the Midline Structures in Chordates: Insights From Gene Regulation in the Floor Plate and Hypochord Homologues of &lt;i&gt;Ciona&lt;/i&gt; Embryos [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.3389/fcell.2021.704367\"\n     onclick=\"log_download('oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021', 'http://doi.org/10.3389/fcell.2021.704367', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('oonuma-yamamoto-moritsugu-okawa-mukai-sotani-tsunemi-sugimoto-etal-evolutionofdevelopmentalprogramsforthemidlinestructuresinchordatesinsightsfromgeneregulationinthefloorplateandhypochordhomologuesoficionaiembryos-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{oonuma_evolution_2021,\n\ttitle = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}: {Insights} {From} {Gene} {Regulation} in the {Floor} {Plate} and {Hypochord} {Homologues} of \\textit{{Ciona}} {Embryos}},\n\tvolume = {9},\n\tissn = {2296-634X},\n\tshorttitle = {Evolution of {Developmental} {Programs} for the {Midline} {Structures} in {Chordates}},\n\turl = {https://www.frontiersin.org/articles/10.3389/fcell.2021.704367/full},\n\tdoi = {10.3389/fcell.2021.704367},\n\tabstract = {In vertebrate embryos, dorsal midline tissues, including the notochord, the prechordal plate, and the floor plate, play important roles in patterning of the central nervous system, somites, and endodermal tissues by producing extracellular signaling molecules, such as Sonic hedgehog (Shh). In\n              Ciona\n              ,\n              hedgehog.b\n              , one of the two\n              hedgehog\n              genes, is expressed in the floor plate of the embryonic neural tube, while none of the\n              hedgehog\n              genes are expressed in the notochord. We have identified a\n              cis\n              -regulatory region of\n              hedgehog.b\n              that was sufficient to drive a reporter gene expression in the floor plate. The\n              hedgehog.b cis\n              -regulatory region also drove ectopic expression of the reporter gene in the endodermal strand, suggesting that the floor plate and the endodermal strand share a part of their gene regulatory programs. The endodermal strand occupies the same topographic position of the embryo as does the vertebrate hypochord, which consists of a row of single cells lined up immediately ventral to the notochord. The hypochord shares expression of several genes with the floor plate, including\n              Shh\n              and\n              FoxA\n              , and play a role in dorsal aorta development. Whole-embryo single-cell transcriptome analysis identified a number of genes specifically expressed in both the floor plate and the endodermal strand in\n              Ciona\n              tailbud embryos. A\n              Ciona\n              FoxA ortholog FoxA.a is shown to be a candidate transcriptional activator for the midline gene battery. The present findings suggest an ancient evolutionary origin of a common developmental program for the midline structures in Olfactores.},\n\turldate = {2021-08-06},\n\tjournal = {Frontiers in Cell and Developmental Biology},\n\tauthor = {Oonuma, Kouhei and Yamamoto, Maho and Moritsugu, Naho and Okawa, Nanako and Mukai, Megumi and Sotani, Miku and Tsunemi, Shuto and Sugimoto, Haruka and Nakagome, Eri and Hasegawa, Yuichi and Shimai, Kotaro and Horie, Takeo and Kusakabe, Takehiro G.},\n\tmonth = jun,\n\tyear = {2021},\n\tpages = {704367},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  In vertebrate embryos, dorsal midline tissues, including the notochord, the prechordal plate, and the floor plate, play important roles in patterning of the central nervous system, somites, and endodermal tissues by producing extracellular signaling molecules, such as Sonic hedgehog (Shh). In Ciona , hedgehog.b , one of the two hedgehog genes, is expressed in the floor plate of the embryonic neural tube, while none of the hedgehog genes are expressed in the notochord. We have identified a cis -regulatory region of hedgehog.b that was sufficient to drive a reporter gene expression in the floor plate. The hedgehog.b cis -regulatory region also drove ectopic expression of the reporter gene in the endodermal strand, suggesting that the floor plate and the endodermal strand share a part of their gene regulatory programs. The endodermal strand occupies the same topographic position of the embryo as does the vertebrate hypochord, which consists of a row of single cells lined up immediately ventral to the notochord. The hypochord shares expression of several genes with the floor plate, including Shh and FoxA , and play a role in dorsal aorta development. Whole-embryo single-cell transcriptome analysis identified a number of genes specifically expressed in both the floor plate and the endodermal strand in Ciona tailbud embryos. A Ciona FoxA ortholog FoxA.a is shown to be a candidate transcriptional activator for the midline gene battery. The present findings suggest an ancient evolutionary origin of a common developmental program for the midline structures in Olfactores.\n</div>\n\n\n</div>\n\n\n\n\n\n  </div>\n\n\n  <!-- Modal -->\n\n  <!-- <iframe id=\"bibbase_network_frame\" -->\n  <!--         src=\"//bibbase.org/network/control\" -->\n  <!--         style=\"display: none;\"> -->\n  <!-- </iframe> -->\n\n</div>\n"}; document.write(bibbase_data.data);